FAST-SeqS: a simple and efficient method for the detection of aneuploidy by massively parallel sequencing.
FAST-SeqS: a simple and efficient method for the detection of aneuploidy by massively parallel sequencing.
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Massively parallel sequencing of cell-free, maternal plasma DNA was recently demonstrated to be a safe and effective screening method for fetal chromosomal red bull spring edition 2022 aneuploidies.Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps with PCR employing a single primer pair designed to amplify a discrete subset of repeated regions.Using this approach, samples containing as little as 4% trisomy 21 DNA wall-e bearbrick could be readily distinguished from euploid samples.
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